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  Új Válasz 2021-08-31 00:46:32 #29578

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  Characterization of C.1.2 lineage

  C.1.2 is highly mutated compared to C.1, and all other VOC and VOI identified to date. Researchers revealed that C.1.2 is phylogenetically more close to the Lambda variant (C.37).
  In May, C.1.2 lineage was detected for the first time in the Mpumalanga and Gauteng provinces of South Africa. Soon after, it was detected in many areas, such as the KwaZulu-Natal and Limpopo provinces of South Africa, as well as in England and China. By August 13, it was found in the majority of South African provinces, including the Eastern Cape and Western Cape. It was also detected in New Zealand, Mauritius, the Democratic Republic of the Congo (DRC), Portugal, and Switzerland.
  ...
  Although C.1.2 shares similar mutations with C.1, it has certain additional mutations within the ORF1ab, spike, ORF3a, ORF9b, E, M, and N proteins. Many of these mutations have occurred in the spike region. More than 50% of the viruses designated to be C.1.2 contain 14 mutations. Researchers have revealed that five of the fourteen mutations are present within the NTD, three within the receptor-binding motif (RBM), and two adjacent to the furin cleavage site. The remaining four mutations are P9L, D614G, H655Y, and T859N.
  Scientists have estimated that 52% of the spike mutations detected in C.1.2 have previously been identified in other VOI and VOC. Some mutations are common between C.1.2 and other VOI and/or VOC. For example, D614G is common across all variants, E484K and N501Y mutations are found in Beta and Gamma variants, N501Y in Alpha, and E484K is found in the Eta variant.

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